Provided is an anti-LAG-3 antibody that can be administered multiple times to animals other than rats. (a) an L chain variable region comprising a CDR1 having the amino acid sequence of QSLLDSDGNTY (SEQ ID NO: 16), a CDR2 having the amino acid sequence of SVS and a CDR3 having the amino acid sequence of MQATHVPFT (SEQ ID NO: 17), and an animal antibody other than rat L chain having an L chain constant region of, (b) CDR1 having the amino acid sequence of GFDFDTYP (SEQ ID NO: 18), CDR2 having the amino acid sequence of ITIKTHNYAT (SEQ ID NO: 19) and the amino acid sequence of NREDFDY (SEQ ID NO: 20) An anti-LAG-3 antibody comprising an H chain having an H chain variable region comprising CDR3 having A pharmaceutical composition comprising the anti-LAG-3 antibody as an active ingredient. A method for preparing the anti-LAG-3 antibody is also provided.
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机译：提供的是一种抗滞后-3抗体，其可以多次向除大鼠以外的动物施用。 （a）包含具有QSLLDSDGNTY（SEQ ID NO：16）的CDR1的CDR1的L链可变区，具有具有氨基酸序列的CDR2和具有MQATHVPFT的氨基酸序列的CDR3（SEQ ID NO： 17）和除了具有L链恒定区域的大鼠L链以外的动物抗体，（b）CDR1具有GFDFDTYP（SEQ ID NO：18）的氨基酸序列，CDR2具有itikthnyat的氨基酸序列（SEQ ID NOR：19）和NREDFDY（SEQ ID NO：20）的氨基酸序列是包含H链可变区的抗滞后-3抗体，所述H链可变区包含具有抗滞后-3抗体的药物组合物作为所述的药物组合物 活性成分。 还提供了制备抗滞后-3抗体的方法。
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