METHOD OF MAKING AN OSTEOCONDUCTIVE FIBROUS ARTICLE AND A MEDICAL IMPLANT COMPRISING SUCH OSTEOCONDUCTIVE FIBROUS ARTICLE

摘要

The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 µm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.;The disclosed methods enable a relatively simple way of providing a complex shaped article like a fibrous article with a bioceramic coating, to result in a modified surface that shows bioactivity, applying biocompatible compounds and mild conditions. The method can be used to make a polyester fibrous article having a coating with bioactive inorganic particles like calcium phosphates to enhance bone growth on the article after implantation.;The disclosure also concerns a fibrous article showing osteoconductive properties, as obtainable with or obtained by said methods, and use of these articles as a component of a medical implant, especially of permanent high-strength orthopedic implants