Chitosan polyplex-based local expression of IL-12 alone or in combination with type-I IFN inducers for the treatment of mucosal cancer

摘要

The present disclosure relates to a polyanion-containing block copolymer reversibly coated with a polyanion-containing block copolymer for use in cancer immunotherapy, preferably for local expression of IL-12 in mucosal tissues in combination with an IFN-1 activator/inducing agent. Compositions and methods comprising derivatized-chitosan polyplexes.