MASP-1 / MASP-2 / MASP-3 COMPOSITIONS AND METHODS OF INHIBITING MASP-1 AND/OR MASP-2 AND/OR MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS

摘要

In one embodiment, the present invention relates to paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis disseminated intravascularity by administering to an individual a composition comprising an amount of MASP-3 in an amount effective to inhibit MASP-3-dependent complement activation. suffering from a disease or disorder selected from the group consisting of coagulation, thrombotic microangiopathy, asthma, compaction disease, minor-immune necrotizing meniscus glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, ankylosing spondylitis and Behcet''s disease; or methods and compositions for inhibiting MASP-3-dependent complement activation in a subject at risk of developing them. In another aspect, the present invention provides an individual suffering from paroxysmal nocturnal hemoglobinuria by administering to the individual a composition comprising an amount of at least one of a MASP-1 inhibitor and/or a MASP-3 inhibitor effective to increase the viability of red blood cells. Provided are methods and compositions for increasing the viability of red blood cells in In some embodiments, a MASP-2 inhibitory and MASP-1 inhibitor, a MASP-2 inhibitor and a MASP-3 inhibitor, a MASP-3 inhibitor and a MASP-1 inhibitor, or a MASP-1 inhibitor, a MASP-2 inhibitory agent and a MASP- 3 Inhibitors are administered.