Pyridine carbonyl derivatives and their therapeutic use as TRPC6 inhibitors

摘要

To provide a pharmaceutical composition for use in the treatment of a disease or disorder that can be alleviated by TRPC6 inhibition, such as cardiac hypertrophy, ischemia, ischemic reperfusion injury, hypertension, pulmonary arterial hypertension, idiopathic pulmonary arterial hypertension, restenosis, chronic obstructive pulmonary disease, cystic fibrosis, Alzheimer's disease, and Parkinson's disease.SOLUTION: A pharmaceutical composition comprises pyridine carbonyl derivatives, for example, a reaction product as follows: [4-(6-amino-4-methyl-pyridazine-3-yl)-piperidine-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridine-2-yl]-methanone, and the like.SELECTED DRAWING: None