Injectable hydrogel composition having endogenous progenitor or stem cell recruitment and induction of vascular differentiation of recruited cells

摘要

The present invention relates to an injection-type hydrogel composition having an endogenous progenitor cell or stem cell trapping ability and an ability to induce vascular differentiation of the captured cells, and more particularly, to an anionic hyaluronic acid into which a vascular differentiation inducer is introduced. first solution; Consists of a second solution containing a cationic biomaterial, and further comprising a stem cell trapping factor in the first solution and/or the second solution, characterized in that the hydrogel is formed by electrostatic attraction It relates to an injection-type hydrogel composition having the ability to trap regenerative progenitor cells or stem cells and the ability to induce vascular differentiation of the captured cells. In the hydrogel composition of the present invention, stem cell trapping factors are released from the injected hydrogel, and endogenous progenitor cells/stem cells are collected in the hydrogel, and differentiated into vascular cells by a vascular differentiation inducing factor chemically introduced into hyaluronic acid. Thus, it was confirmed that the induction of angiogenesis was promoted, and in particular, it was confirmed that a high angiogenesis-inducing effect was exhibited when a vascular differentiation inducing factor was chemically introduced into hyaluronic acid. Therefore, the hydrogel composition of the present invention has excellent intrinsic progenitor/stem cell trapping ability and vascular differentiation inducing ability, and thus can be usefully applied to various tissue regeneration and wound treatment in addition to blood vessel formation.