HUMAN GENETIC MARKERS ASSOCIATED WITH RESPONSE TO TREATMENT AGENTS THAT TARGET TOXIN B CLOSTRIDIUM DIFFICILE

摘要

FIELD: biotechnology.;SUBSTANCE: present invention relates to biotechnology, in particular to genetic markers on the 6th human chromosome that are associated with a favorable response to the treatment that purposefully affects toxin B Clostridium difficile (C. difficile) (TcdB), for example, an antibody to TcdB. These markers of the response to TcdB treatment are useful, among other things, for identifying patients who are most likely to be favorably affected by treatment using a treatment agent that specifically affects TcdB. The present invention also relates to antibodies, drugs and kits suitable together with markers of the response to TcdB treatment according to the present invention.;EFFECT: obtaining genetic markers for TcdB treatment.;30 cl, 11 dwg, 9 tbl, 5 ex