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POLYGENIC TRAIT PREDICTION USING LOCAL ANCESTRY
POLYGENIC TRAIT PREDICTION USING LOCAL ANCESTRY
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机译:使用当地血统的多基因特征预测
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摘要
Provided herein are methods for determining polygenic traits and risks for medical use, such as cancer traits and risks, as well as treating diseases for which risk is identified and/or assessed. Methods of this invention can provide a polygenic score which takes into account local ancestry through the ancestral origin of the alleles of risk loci. A polygenic score can provide surprisingly increased accuracy in determining polygenic traits and risks for ancestrally admixed populations.
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