DRUG-LIKE MOLECULES AND METHODS FOR THE THERAPEUTIC TARGETING OF VIRAL RNA STRUCTURES

摘要

Methods for identifying selective RNA-binding small molecules by NMR screening. The method provides a screening cascade to identify molecules that bind to an RNA structure, such as HIV TAR. Compounds that bind to structured RNAs and that are useful to disrupt the formation of RNA-protein complexes, such as P-TEFb-Tat-TAR complex.