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MODULAR PLATFORM FOR PROGRAMMABLE SPATIOTEMPORAL BIOMOLECULE CLUSTERING WITH APPLICATIONS INCLUDING ENHANCED METABOLIC YIELD
MODULAR PLATFORM FOR PROGRAMMABLE SPATIOTEMPORAL BIOMOLECULE CLUSTERING WITH APPLICATIONS INCLUDING ENHANCED METABOLIC YIELD
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机译:用于可编程时空生物分子聚类的模块化平台,包括增强的代谢产量
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摘要
Provided herein are programmable condensate protein systems and nucleic acid constructs encoding the same. The protein system enables modular targeting of proteins of interest. Protein-peptide interaction domains (PPIDs) are incorporated to functionalize engineered condensates with the attributes of the recruited protein, resulting in a modular system that allows for diverse facile and reprogrammable applications, including in enzyme clustering of metabolic pathways. Colocalizing specific metabolic enzymes in these condensates results in functionalized organelles with which can be used to manipulate the output of engineered metabolic pathways for the production of a pharmaceutical precursor.
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