DOTA synthesis

摘要

PROBLEM TO BE SOLVED: To provide a method for synthesizing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and a metal chelate thereof. A method for synthesizing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), wherein the method is (a) 1,4. , 7,10-Tetraazacyclododecane (cyclene) with haloacetic acid and / or a salt thereof and an excess base; (b) A step of crystallizing the reaction mixture obtained in step (a). The crystallization is carried out at pH> 3 and <3.5; (c) the step of filtering the aqueous solution of the product obtained by the crystallization of step (b) using membrane filtration. (D) A method comprising the step of crystallizing the filtered solution obtained in step (c). [Selection diagram] None