A backlight drive method, a backlight drive device, a backlight source system, and a display device are provided in the present disclosure. The backlight drive method is used to drive a light-emitting region of a backlight source of the display device. Driving the light-emitting region of the backlight source includes acquiring actual ambient brightness of an ambient where the display device is located. Driving the light-emitting region of the backlight source further includes determining a target backlight brightness range of light exited from the light-emitting region with reference to the actual ambient brightness, where the target backlight brightness range is within an intrinsic brightness range of the light-emitting region. Driving the light-emitting region of the backlight source further includes matching the target backlight brightness range to a plurality of gray levels preset in the light-emitting region.
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