Method for evaluating the quality of neural retina for implantation and neural retina sheet for implantation

摘要

The method for evaluating the quality of a neural retina for transplantation of the present invention includes extracting a part or all of a cell aggregate comprising a neural retina having an epithelial structure derived from pluripotent stem cells as a sample for quality evaluation, and a sample for quality evaluation When the expression of a neuroretinal cell-related gene and a non-neural retinal cell-related gene is detected, and the expression of a neuroretinal cell-related gene is confirmed and the expression of a non-neural retinal cell-related gene is not confirmed. , (1) neural retina (neural retina for transplantation) in the same cell aggregate as the cell aggregate containing the sample for quality evaluation which is a part, and (2) the cell aggregate containing the sample for quality evaluation as a part and in the same lot of cell aggregates It is said that the neural retina (neural retina for transplantation) in a neural retina (neural retina for transplantation) or (3) the neural retina (neural retina for transplantation) in the cell aggregate of the whole quality evaluation sample and the same lot of cell aggregates can be used as a neural retina for transplantation. and determining, wherein the non-neural retinal cell-related gene includes one or more genes selected from the group consisting of a cerebrospinal cord tissue marker gene and an eye-related tissue marker gene.