Biomarkers in blood for diabetic macular edema and uses thereof

摘要

In the present invention, amino acids, organic compounds, and oxylipin, which were statistically significantly differentiated from the control group among blood metabolites in type 2 diabetes patients, were selected. Among them, asparagine, aspartic acid, glutamic acid, cysteine, lysine, citric acid and uric acid and oxylipin 12-oxo ETE ( 12-oxo ETE), 15-oxo ETE (15-oxo ETE), 9-oxo ODE (9-oxo ODE) and 20-carboxy leukotriene B4 (20-carboxy leukotriene B4) It was confirmed that the cutoff value of AUC>0.7 The above blood metabolites showed a significant difference between the DME patient group and the non-DME patient group, confirming that it can be used for accurate diagnosis of DME.