- Recombinant protein fused with interferon-beta mutein and antibody and pharmaceutical composition comprising the same

摘要

The present invention relates to a recombinant protein, a polynucleotide, an expression vector and a recombinant microorganism in which an antibody binding to a specific antigen is fused with an interferon-beta variant substituted with an amino acid residue, and a pharmaceutical composition for anticancer comprising the recombinant protein as an active ingredient. , The recombinant protein may improve the physical properties of interferon-beta through site-specific mutation, thereby improving biological activity and purification efficiency, and increasing productivity. Since these recombinant proteins express both the function of interferon-beta and the characteristics of an antibody binding to a specific antigen, it can be usefully used as a target therapeutic agent for cancer and the like.