-L1CAM Anti-L1CAM Antibody or Antigen Binding Fragment Thereof and Chimeric Antigen Receptor Comprising The Same

摘要

The present invention relates to an anti-L1CAM antibody or antigen-binding fragment thereof that specifically binds to an L1CAM antigen, a chimeric antigen receptor comprising the same, and uses thereof. Since the anti-L1CAM antibody or antigen-binding fragment thereof of the present invention has excellent specificity and affinity for L1CAM, it can be used for the treatment and diagnosis of diseases related to various cancers and inflammatory diseases related to high L1CAM expression. In particular, when the chimeric antigen receptor containing the anti-L1CAM antibody of the present invention is expressed in effector cells such as T lymphocytes, it can be usefully used as an immunotherapy method for various cancers and inflammatory diseases related to L1CAM.