BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE

摘要

Herein, a therapeutically effective amount of a surface sodium-dependent bile acid transporter inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof to treat hypercholemia or cholestatic liver disease. A method of treating or ameliorating Also treating or ameliorating a liver disease, lowering serum bile acid or hepatic bile acid level, or treating pruritus comprising administering to a subject in need thereof a therapeutically effective amount of an ASBTI or a pharmaceutically acceptable salt thereof. or to improve, reduce liver enzymes, or reduce bilirubin.