FETAL CELL CAPTURE MODULE AND MICROFLUIDIC CHIP FOR FETAL CELL CAPTURE AND METHODS FOR USING THE SAME

摘要

The present invention provides a fetal cell capture module and a microfluidic chip for fetal cell capture and methods for using the same. The fetal cell capture module comprises a cell capture carrier and a recognition molecule for specifically capturing cells, wherein the recognition molecule is connected to the carrier surface via an organic conjugate containing a disulfide bond. The surface of the microfluidic chip for fetal cell capture is modified by the organic conjugate containing the disulfide bond to specifically capture the recognition molecule of the fetal cells, and after the recognition molecule captures the cells, the cells are released by chemical cleavage of disulfide bond in the organic conjugate. The capture module, the microfluidic chip and the use of the capture module and the microfluidic chip can realize capture of the fetal cells of whole blood without pretreatment, the capture rate is high, the cell loss is small, the cell release operation is simple, the action is accurate, and therefore making possible efficient and lossless release and whole genome analysis of the fetal cells.