USE OF BRAIN-SPECIFIC ANTIGENS TO HOME, BLOCK AND DELIVER CELL-BASED TREATMENTS TO THE BRAIN

摘要

Provided herein is a cell comprising a recombinant nucleic acid encoding a transmembrane protein that has an extracellular binding domain that specifically binds to a brain-selective extracellular antigen, e.g., MOG, CDH10, PTPRZ1 or NRCAM, wherein the cell does not comprise a nucleic acid encoding an antigen-specific therapeutic that binds to a killing antigen expressed by a glioblastoma.