Composition for antibacterial activity of multi-drug resistant bacteria

摘要

The present invention relates to an antimicrobial composition having antibacterial activity against antibiotic-resistant strains, and more particularly, to a composition comprising an antimicrobial compound exhibiting antimicrobial activity targeting the cell membrane of multidrug-resistant bacteria of gram-positive bacteria. The composition contains triphenylphosphonium (TPP + ), which is a positively charged lipophilic cationic compound and targets mitochondria, and thus targets the anionic lipids of the cell membrane of bacteria, Gram-positive bacteria, particularly Staphylococcus aureus and It shows a low MIC value for metacillin-resistant Staphylococcus aureus and shows antibacterial activity by inhibiting the outflow of antibiotics introduced into cells by reducing the expression of drug outflow genes. Applicable.