Pharmaceutical preparations for use in the treatment of Epstein Barr virus positive patients with diseases associated with reactivation events

摘要

The present invention relates toAt least in B cells of Epstein Barr virus (EBV)AndFor use in the manner of potentially treating patients suffering from diseases and / or disorders associated with reactivation in other sensitive cells, such as sensitive epithelial cellsAn isolated trifunctional dual specificity antibodySaid methodProviding an autologous cell preparation of the patient's enriched B cell andFor the enriched B cellTogether with the tritium double special antibodyIncubated for a sufficient period of time to establish the physical interaction between the tritium double specific antibody and the enriched B cellGetting the incubation mix andIncluding the incubation of the incubation mixture obtained after incubation to the same patientThe tritium double specific antibody(a) first binding arm binding to B cells via B cell surface antigen(b) a second binding arm coupled to T cells via T cell surface antigen(c) includes an Fc portion binding to Fc receptor positive cellsAntibodies are disclosed.The present invention also discloses a pharmaceutical composition comprising said isolated three functional dual specificity antibody for use in the treatment of patients suffering from diseases and / or disorders associated with reactivation in B cells of EBV and an ex vivo method for preparing the pharmaceutical composition.No selection