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COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS IN ANAEROBIC CELLS AND RELATED CLINICAL METHODS FOR TREATING CANCER AND PATHOGENIC INFECTIONS
COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS IN ANAEROBIC CELLS AND RELATED CLINICAL METHODS FOR TREATING CANCER AND PATHOGENIC INFECTIONS
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机译:诱导厌氧细胞细胞凋亡的组合物和方法及治疗癌症和致病感染的相关临床方法
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摘要
The invention provides potent anti-cancer methods and compositions that employ novel glycome compounds exemplified by glyco-benzaldehydes that disrupt anaerobic respiration and trigger apoptosis in cancer cells. Additionally, the invention provides useful compositions and methods to treat viral and microbial infections, and for enhancing suppressed immune systems, including by disrupting alpha-N-acetylgalactosaminidase (nagalase) function and lowering circulating nagalase blood levels. In certain anti-cancer and immune enhancing methods and compositions of the invention glyco-benzaldehyde compounds, such as the plant-derived glyco-benzaldehyde helicidum, are employed, alone or in combination, to potently destroy tumors and circulating cancer cells, and significantly prolong survival of cancer patients, including treatment-resistant Stage III and Stage IV cancer patients.
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