首页>
外国专利>
IMMORTALIZED CAR-T CELLS GENETICALLY MODIFIED TO ELIMINATE T-CELL RECEPTOR AND BETA 2-MICROGLOBULIN EXPRESSION
IMMORTALIZED CAR-T CELLS GENETICALLY MODIFIED TO ELIMINATE T-CELL RECEPTOR AND BETA 2-MICROGLOBULIN EXPRESSION
展开▼
机译:永生化的Car-T细胞遗传修饰以消除T细胞受体和β2-微球蛋白表达
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention pertains to engineered immortalized T-cell lines, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered immortalized T-cell lines of the invention are characterized in that the expression of endogenous T-cell receptors (TCRs) and beta 2-microglobulin (B2M) is inhibited, e.g., by using an endonuclease able to selectively inactivate the TCR and B2M genes in order to render the immortalized T-cells non-alloreactive. In addition, expression of immunosuppressive polypeptide can be per-formed on those engineered immortalized T-cells in order to prolong the survival of these T-cells in host organisms Such engineered immortalized T-cells are particularly suitable for allogeneic transplantations, especially because it reduces both the risk of rejection by the hosts immune system and the risk of developing graft versus host disease. The invention opens the way to standard and affordable adoptive immunotherapy strategies using immortalized T-cells for treating cancer, infections and auto-immune diseases.
展开▼