USE OF MUTANT P53 GENE TARGETED LEAD BORATE NANOPARTICLES IN CANCER TREATMENT AND PRODUCTION METHOD OF THESE NANOPARTICLES

摘要

The present invention relates to use of nano-sized lead borate compounds for treatment purposes due to their selective anticancer activity on p53 mutant breast cancer cell line, T47D. The method of synthesizing nano-sized lead borates of the present invention comprises the steps of preparing a borate buffer solution by sodium hydroxide and boric acid, dissolving lead nitrate (and preferably PEG) in distilled water by stirring, mixing the borate buffer solution with the lead nitrate (and preferably PEG) solution, washing the resulting solution with distilled water and drying to remove the impurities.