A composition for treating cancer in which an anti-CD26 antibody and another anti-cancer agent are combined.

摘要

An object of the present invention is to provide a novel highly safe method for treating mesothelioma. CD26 is overexpressed in mesothelioma and is considered to be highly safe. It has been revealed that the mesothelioma growth inhibitory effect of standard cisplatin-pemetrexed concomitant therapy is potentiated by combination with an anti-CD26 antibody. As a result of studying the effect of a humanized CD26 antibody and gemcitabine used concomitantly on the growth of a mesothelioma cell line, it has been found that a method for treating mesothelioma with a high therapeutic effect and excellent safety can be provided by the concomitant use of an anti-CD26 antibody and gemcitabine. As a result of conjugating an anti-CD26 antibody (YS110) with triptolide via a divalent cross-linking agent for concomitant therapy using the anti-CD26 antibody, a novel antibody-drug conjugate (Y-TR1) very highly effective for CD26-positive malignant mesothelioma cells has been successfully obtained.