Thermosponge nanoparticle platform coated with chitosan for delivery bioactive materials and its use

摘要

The present invention relates to a chitosan coated thermosponge nanoparticle (CTNP) platform for drug delivery and uses thereof. The temperature-sensitive nanosponge platform coated with chitosan for delivery of physiologically active substances according to the present invention has improved cellular uptake, so that more drugs, for example, anticancer drugs, can be delivered into cells, and p-gp inhibition is weakly performed by Pluronic. It can effectively treat drug-resistant tumor cells without a separate p-gp inhibitor.