RECTAL APPLICATION OF THALIDOMIDE IN PATIENTS WITH HEMORRHAGIC CHRONIC RADIATION PROCTITIS

摘要

Hemorrhagic chronic radiation proctitis is a long-term side effect of radiotherapy in the treatment of pelvic malignancies. The present invention pertains to the therapeutic use of thalidomide or an analogue thereof for treating hemorrhagic chronic radiation proctitis, wherein said treatment comprises rectally administering said thalidomide or its analogue to a patient in need thereof. Topical treatment of the areas affected by hemorrhagic chronic radiation proctitis with thalidomide leads to a long lasting decay of the hemorrhagic chronic radiation proctitis and healing of the affected tissue.