Method for treating hyperlipidemia using angptl8 inhibitor and ANGPTL3 inhibitor

摘要

The present invention is a method for treating a patient suffering from hyperlipidemia, wherein said patient is non-responsive or standard to treatment with standard lipid modification therapy. Provided that said method is poorly controlled by treatment with any of the lipid-modifying therapies or is intolerant of treatment with standard lipid-modifying therapies. The method of the present invention is combined with a therapeutically effective amount of an antibody that specifically binds to angiopoietin-like protein 3 (ANGPTL3), and a therapeutically effective antibody or antigen-binding fragment thereof that specifically binds to angiopoietin-like protein 8 (ANGPTL8) By administering an amount, at least one lipid parameter is reduced in the patient. The combination of anti-ANGPTL8 antibody with anti-ANGPTL3 antibody is hypercholesterolemia including both heFH and hoFH which are familial hypercholesterolemia (FH), and hyperlipidemia including hypertriglyceridemia, chylomicronemia It is also useful in treating diseases such as hyperlipidemia and dyslipidemia, as well as preventing or treating diseases or disorders in which abnormal lipid metabolism such as cardiovascular disease is a risk factor.