首页>
外国专利>
Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
展开▼
机译:治疗线粒体神经元心电图脑病的组合物和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Disclosed herein are compositions and methods of treating disclosure provides for compounds for use in treating Mitochondrial Neurogastrointestinal Encephalopathy Syndrome (MNGIE). In some embodiments, the compounds have cell penetrating activity and thymidine phosphorylase activity. In certain embodiments, the compounds disclosed herein comprise: a) at least one cell-penetrating peptide (CPP) moiety; and b) a thymidine phosphorylase, or an active fragment or analog thereof (TP), wherein the CPP is coupled, directly or indirectly, to TP.
展开▼