SPINOSYN DERIVATIVE AS ARGININOSUCCINATE SYNTHETASE ACTIVATOR AND APPLICATION THEREOF

摘要

Spinosyn A and a derivative thereof as activators of argininosuccinate synthetase 1 (ASS1) and mutant ASS1 G362V and an application thereof, the Spinosyn derivative having the general structural formula (I). Spinosyn and the derivative thereof can be used as a drug for the treatment of citrullinemia type I and as an anti-tumor drug by targeting the activation of ASS1 and mutant ASS1 G362V.