SEMI-SOLID FORMULATION FOR VOLUNTARY ORAL ADMINISTRATION OF BIOACTIVE COMPOUNDS TO RODENTS

摘要

This application relates to a formulation for voluntary oral administration of bioactive compounds to rodents. The semid-solid formulation disclosed in the presente patent application comprises at least one thickening agent, a digestible sweetener selected from sucralose and calcium saccharin, a diluent agent, wherein the diluent agent is a powder with a granulometry between 300 and 800µm, obtained from finely grounded seeds, cereal grains or cereal grain based diet for rodents, at least one flavor masking agent and a bioactive compound. The presently disclosed semi-solid formulation has shown promote voluntary feeding in rodents regardless of the bioactive compounds contained therein and without disruption of the metabolic pathways, therefore said semi-solid formulation has shown to be ideal for use in the oral administration of drugs and bioactive compounds to rodents. Use of said semi-solid formulation in the production of toxicant baits for rodents is also envisioned.