Method for clustering large-scale multiple spatial decomposition data of biological sample and computer program

摘要

The present invention relates toWith respect to the method of processing large-scale multiple image data of biological samplesThe above methodThe following steps: registering multiple images of biological samples;The multiple images areSaid step consisting of an image having different objects in biological samples targeted by a prescribed stainDetermining an image pixel corresponding spatially in the plurality of registered images;The spatially corresponding image pixel is associated with the pixel profile;Each pixel profile isContains pixel values of the spatially corresponding pixels;The pixel profile isSaid step associated with the coordinates of each image of the spatially corresponding pixelA pixel method is pooled by a clustering method configured to determine a pixel profile having a similar valueThereby generating multiple clusters, each including pixel profiles having similar pixel values;For each clusterThe cluster value is assigned to the coordinates of the image of the pixel profile constructed by the clusterThe method includes generating a cluster image having cluster pixels.Selection diagram