CELL MEMBRANE LIPID-EXTRACTED NANOPARTICLES (CLENS) FOR SELECTIVE TARGETING, IMAGE ANALYSIS AND CANCER THERAPY

摘要

Nanoliposome compositions and methods of making the same for selective targeting, image analysis and therapy (e.g., cancer therapy) are provided. In some aspects, the nanoliposomes comprise membrane material derived from cells (e.g., tumor cells) in order to selectively target agents (e.g., chemotherapeutic agents) to cancer cells. Membranes used to generate the nanoliposomes provided herein may be derived from cells in vivo, ex vivo, or in vitro. The disclosure also provides pharmaceutical compositions comprising nanoliposomes and methods of treatment by administering the same.