CLEARANCE OF SENESCENT CELLS BY ACTIVATION OF iNKT CELLS

摘要

Activated iNKT cells act as senolytic agents, removing senescent cells from target tissues, organs, and compartments of the body. Provided are methods of clearing pathological accumulations of senescent cells by administration of iNKT cell activators such as an alpha-galactosylceramide, or variants or by the adoptive transfer of iNKT cells or precursors, enabling the treatment of senescence-associated conditions such as diabetes, lung fibrosis, and other conditions.