A method of therapeutic administration of neuregulin or its fragments for the treatment or prevention of heart failure

摘要

Problem to be solved: to provide a method for treatment and prevention of heart failure in mammals.A method for treating or preventing cardiac insufficiency in the subject, including the step of administering a therapeutically effective amount of peptide to an object that requires it, the peptide comprising an epidermal growth factor like (EGF like) domain, which has an effective dose of about 0.005 mg / kg body weight to about 4 mg / kg body weight The method in which the peptide is administered at an administration interval of at least 24 hours.The therapeutic regimen given by administration of neuregulin, such as glial growth factor 2 (GGF. Sub.2) or its functional fragment, is maintained and / or enhanced by the administration regimen Any potential side effect is minimized simultaneously.Selection diagram