System, Method and Computer Readable Medium to Estimate the Post-Treatment Blood Cell Sub Type Count in Patients Treated via Radiation Therapy

摘要

A system, method, and computer readable medium for estimating the patient specific and plan specific radiation dose delivered to any type of circulating blood cell type or sub-type, such as, but not limited to, T lymphocytes, B lymphocytes, natural killer cells, erythrocytes, or neutrophils, and predicting time dependent fractional blood count and cell kill following radiation therapy treatment. Additionally, the system, method, and computer readable medium provide parameters such as a dose dependent lymphocyte kill function and average net release rate of new lymphocytes into circulating blood, which also includes the proliferation of existing cells and natural death of lymphocytes in blood. Determining lymphocyte kill following Stereotactic Body radiation therapy (SBRT) to lung tumors is an example of an application of the system, method, and computer readable medium.