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METHODS OF IDENTIFYING PARKIN-MEDIATED MITOPHAGY ACTIVATING AGENTS
METHODS OF IDENTIFYING PARKIN-MEDIATED MITOPHAGY ACTIVATING AGENTS
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机译:鉴定Parkin介导的MITOCHAGY活化剂的方法
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摘要
This disclosure provides a screening method to identify Parkin-mediated mitophagy activating agents wherein the method comprises contacting cells exogenously expressing labelled mutant Parkin polypeptide with a test agent and a mitophagy inducing agent, and measuring the amount of Parkin polypeptide recruited to mitochondria in the cells. Also provided is a kit comprising a plasmid, recombinant cells, a multi-well plate, a pintool head, cells expressing wildtype Parkin, and transfection reagents.
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