In some examples, human centered computing based digital persona generation may include generating, for a digital persona that is to be generated for a target person, synthetic video files and synthetic audio files that are combined to generate synthetic media files. The digital persona may be generated based on a synthetic media file. An inquiry may be received from a user of the generated digital persona. Another synthetic media file may be used by the digital persona to respond to the inquiry. A real-time emotion of the user may be analyzed based on a text sentiment associated with the inquiry, and a voice sentiment and a facial expression associated with the user. Based on the real-time emotion of the user, a further synthetic media file may be utilized by the digital persona to continue or modify a conversation between the generated digital persona and the user.
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