METHOD AND SYSTEM FOR CONTROLLING MOLECULAR ELECTROTRANSFER

摘要

A system and method of controlling electrotransfer delivery of therapeutic molecules to targeted groups of cells. The system has an array of two or more electrodes configured to be inserted into biological tissue and a pulse generator configured to drive the two or more electrodes. A first selection of electrodes is determined, and for the selected electrodes, electrical pulse parameters to generate a first shaped electric field for a target treatment region adjacent the array are determined. A second selection of electrodes is determined, and for the selected electrodes, electrical pulse parameters are determined to generate a second shaped electric field for a target treatment region adjacent the array. The pulse generator is controlled to apply a first sequence of unipolar pulses using the first selection of electrodes to generate a first shaped electric field, and a second sequence of unipolar pulses using the second selection of electrodes to provide a second shaped electric field..