ENANTIONSELECTIVE PROCESSES TO INSECTICIDAL 3-ARYL-3-TRIFLUOROMETHYL-SUBSTITUTED PYRROLIDINES

摘要

The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermedates in the processes. The processes include those comprising(a-i) reacting a compound of formula IawhereinP is alkyl, aryl or heteroaryl, each optionally substituted, wherein the heteroaryl is connected at P via a ring carbon atom;R1 is chlorodifluoromethyl or trifluoromethyl;R2 is aryl or heteroaryl, each optionally substituted;with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIawherein P, R1 and R2 are as defined for the compound of formula Ia; and(a-ii) oxidising the compound of formula IIa with a peroxy acid, or peroxide in the presence of an acid to give a compound of formula VIwherein R1 and R2 are as defined for the compound of formula Ia.