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CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular Cas enzymes
CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular Cas enzymes
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机译:CRISPR-CAS系统和改变基因产物表达,结构信息和诱导性模块化CAS酶的表达的方法
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摘要
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends the engineering of optimized modular CRISPR-Cas enzyme systems.
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