Cytotoxic protein containing cell targeted binding region and Shiga toxin A subunit region for selective death of specific cell types

摘要

Selective cytotoxicity of specific cell types also provides cytotoxic proteins that are useful as therapeutic agents for the treatment of various diseases, such as cancer, immune disorders and microbial infections.A) an immunoglobulin binding region comprising one or more polypeptides and capable of specifically binding to at least one extracellular target biomolecule B) is a cytotoxic protein that contains the Shiga toxin effector region containing polypeptides derived from the amino acid sequence of the a subunit of the at subunit of the Shiga toxin family.Diagram