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NONINVASIVE DETECTION OF CANCER ORIGINATING IN TISSUE OUTSIDE THE LUNG USING EXHALED BREATH
NONINVASIVE DETECTION OF CANCER ORIGINATING IN TISSUE OUTSIDE THE LUNG USING EXHALED BREATH
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机译:使用呼出气孔的肺部外部组织中的癌症的非侵入性检测
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摘要
Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.
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