IDENTIFICATION AND TARGETING OF TUMOR PROMOTING CARCINOMA ASSOCIATED FIBROBLASTS FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES

摘要

Provided herein are agents, such as antibodies or chimeric antigen receptors, that target TP-CAFs. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of a TP-CAFs-neutralizing agent. The methods can further include administering an effective amount of chemotherapy or immunotherapy to said patient. The methods can include administering an IL-6 signaling inhibitor in combination with an immune checkpoint blockade therapy.