Use of ACE2 as treatment of COVID-19

摘要

The present invention relates to the use of ACE2 as a therapeutic agent for coronavirus infection-19, and specifically, the present invention comprises a recombinant ACE2 protein or a recombinant ACE2-Fd fusion protein as an active ingredient, for preventing or treating coronavirus infection-19 It relates to pharmaceutical compositions. The recombinant ACE2 protein and the recombinant ACE2-Fd fusion protein according to the present invention are obtained by expression and purification from a plant, and both of the recombinant ACE2 and ACE2-Fd fusion proteins have excellent antiviral activity against SARS-CoV-2 virus. , By confirming the improvement effect of inflammatory lesions in the lung tissue of an animal model infected with SARS-CoV-2 virus, there is an effect that these recombinant proteins can be used as new therapeutic agents for COVID-19 infection.