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Aromatic ring or heteroaromatic ring compound, preparation method thereof and medical use thereof

机译:芳香环或杂芳环化合物,其制备方法及其医疗用途

摘要

The present invention relates to an aromatic ring or heteroaromatic ring compound, a process for the preparation thereof and a medical use thereof. In particular, the present invention relates to compounds of formula (I): The compound and the pharmaceutical composition comprising the compound are FXR activity-related diseases such as cholestasis syndrome, diabetes and its complications, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatosis hepatitis (NASH), obesity or metabolic syndrome (dyslipidemia, diabetes, diseases associated with abnormally high body weight index), cardiovascular diseases, and the like. The definition of each substituent of formula (I) is as described in the specification: [Formula I] .
机译:本发明涉及芳环或杂芳环化合物,其制备方法及其医疗用途。 特别地,本发明涉及式(I)化合物:包含该化合物的化合物和药物组合物是FXR活性相关的疾病,如胆汁淤积综合征,糖尿病及其并发症,非酒精性脂肪肝病(NAFLD), 非酒精性脂肪变性肝炎(肿瘤),肥胖症或代谢综合征(血脂血症,糖尿病,与异常高的体重指数相关的疾病),心血管疾病等。 式(I)的每种取代基的定义如说明书:[公式I]中所述。

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