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VIRUS TREATMENT METHODS, AND RELATED PHARMACEUTICAL COMPOSITIONS, VACCINE COMPOSITIONS, SANITIZING COMPOSITIONS, AND DRUG DISCOVERY METHODS
VIRUS TREATMENT METHODS, AND RELATED PHARMACEUTICAL COMPOSITIONS, VACCINE COMPOSITIONS, SANITIZING COMPOSITIONS, AND DRUG DISCOVERY METHODS
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机译:病毒处理方法,以及相关的药物组合物,疫苗组合物,消毒组合物和药物发现方法
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摘要
Pharmaceutical compositions comprising at least one calcium chelating agent such as disodium ethylenediamine tetraacetate (Na2EDTA) as an active pharmaceutical ingredient, are described that are useful for treating an infection by single stranded RNA virus, such as SARS-COV-2, are described. Development of the compositions was assisted by using a novel dmg discovery method which utilizes the characterization of a common molecular mechanism in a cohort of an unforeseen clinical co-morbidly patterns identified as outliers. Reverse engineering of the outlier cohort yielded unrecognized calcium requirements for infection by SARS-CoV-2 provided a common molecular mechanism in the outlier group that enabled formulation of the new pharmaceutical compositions.
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