A method includes: obtaining a plurality of clinical red blood cell images, dividing red blood cells of different shapes at different positions in each of the red blood cell images into a plurality of submasks, and synthesizing the submasks corresponding to each of the red blood cell images to generate one mask to obtain a plurality of masks corresponding to the red blood cell images; collecting shape data of a plurality of red blood cells from the masks to obtain a training data set, calculating a segmentation boundary of each red blood cell in the training data set, and establishing a red blood cell shape data set based on the segmentation boundary of each red blood cell; collecting distribution data of each red blood cell in the red blood cell shape data set; and synthesizing the red blood cell shape data set into a plurality of red blood cell images.
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