METHOD FOR ASSESSING RISK OF BACTERICIDAL COMPLICATIONS IN PATIENTS WITH HIV INFECTION DURING OPIOID WITHDRAWAL SYNDROME

摘要

FIELD: medicine.;SUBSTANCE: invention relates to the field of medicine, in particular to infectology. A method for assessing the risk of bacterial complications in patients with HIV infection during the period of opioid withdrawal syndrome is proposed. The level of endotoxin-mediated activation of monocytes is determined. The concentration of the soluble CD14 receptor in blood plasma is measured twice: during the clinical peak of the withdrawal syndrome on day 3-5 and during the transition to the post-abstinent state on day 10-14. With a decrease in the concentration of CD14 in blood plasma below 1388 ng/ml, at least one of the two definitions assesses a decrease in endotoxin-mediated immune activation and an increased risk of bacterial complications. ;EFFECT: invention makes it possible to more accurately determine the immune status of HIV patients undergoing detoxification therapy for opioid withdrawal syndrome in drug treatment departments; expands the possibilities of predicting bacterial complications in the post-withdrawal period. ;1 cl, 1 ex