NON INVASIVE METHODS FOR DIAGNOSING LIVER FIBROSIS

摘要

The invention relates to a method comprising a) providing a blood sample from a subject b) determining the level of CPS-1 expression in said sample c) comparing the level of CPS-1 expression of (b) to the level of CPS-1 expression determined from a blood sample from a subject with mild to moderate fibrosis of the liver d) determining the level of glutamate in said sample e) comparing the level of glutamate of (d) to level of glutamate determined from a blood sample from a subject with mild to moderate fibrosis of the liver f) wherein if the level of glutamate of (d) and CPS-1 expression of (b) is higher than the level of glutamate and CPS-1 expression from a blood sample from a subject with mild to moderate fibrosis of the liver, it is inferred the subject has increased likelihood of having advanced or severe (F3/F4) fibrosis of the liver.